The Nice Alzheimer’s Rip-off and the Confirmed Cures They’ve Buried for Billions

Medication is strongly biased in the direction of adopting biochemical fashions of illness as this facilitates expensive therapeutics being developed for every illness and therefore sustains the medical trade. Sadly, in lots of instances, the biochemical method to illness, at greatest, can handle signs, and in consequence, many situations stay “incurable” whereas non-patentable pure therapies that may remedy them languish in obscurity.

That’s why, regardless of spending an ever rising sum of money on Alzheimer’s analysis (e.g., the NIH spent 2.9 billion in 2020 and three.9 billion in 2024¹), we’ve nonetheless did not make any actual progress on the illness. That is notably exceptional given the huge prices to the nation (e.g., final yr Alzheimer’s was estimated to value the USA 360 billion {dollars}²) and the even higher social prices that accompany it.

The Amyloid Juggernaut

In 1906, plaques (of amyloid) within the mind have been recognized as the reason for Alzheimer’s illness. Because the years have passed by, nearly all of analysis for treating Alzheimer’s illness has been focused at eliminating these plaques. Sadly, to cite a 2022 article:³

“A whole lot of medical trials of amyloid-targeted therapies have yielded few glimmers of promise, nonetheless; solely the underwhelming Aduhelm has gained FDA approval. But Aβ nonetheless dominates analysis and drug growth. NIH spent about $1.6 billion on tasks that point out amyloids on this fiscal yr, about half its total Alzheimer’s funding.

Scientists who advance different potential Alzheimer’s causes, akin to immune dysfunction or irritation, complain they’ve been sidelined by the ‘amyloid mafia.’ Forsayeth says the amyloid speculation turned ‘the scientific equal of the Ptolemaic mannequin of the Photo voltaic System,’ by which the Solar and planets rotate round Earth.”

Notice: Often, when a defective paradigm fails to clarify the illness it claims to deal with, somewhat than admit the paradigm is flawed, its adherents will label every conflicting piece of proof as a paradox (e.g., the French “paradox” disproves the notion ldl cholesterol causes coronary heart illness⁴) and dig deeper and deeper till they’ll discover one thing to proceed propping up their ideology (e.g., ldl cholesterol lowering statins present virtually no profit for coronary heart illness whereas having important unwanted side effects but proceed being pushed on sufferers).

The constant failure of the amyloid mannequin to remedy Alzheimer’s step by step invited rising skepticism in the direction of it, which resulted in increasingly more scientists learning different fashions of the illness. Earlier than lengthy, they discovered different components performed a much more important position in inflicting the illness (e.g., power irritation), and by 2006, this angle appeared poised to alter the path of Alzheimer’s analysis.

In response, the amyloid proponents pivoted to defending their failed speculation was due to not amyloid clumps, however somewhat poisonous components of it (oligomers) and a Nature 2006 paper appeared which recognized a beforehand unknown poisonous oligomer, Aβ*56, and supplied proof that it brought on dementia in rats.⁵

This paper cemented each the amyloid beta and poisonous oligomer hypotheses (because it supplied the proof many adherents to the idea had been ready for) and quickly turned some of the cited works within the subject of Alzheimer’s analysis. Its authors rose to tutorial stardom, produced additional papers validating their preliminary speculation, and billions extra have been invested by each the NIH and the pharmaceutical trade in analysis of the amyloid and poisonous oligomer speculation.

It ought to be famous that some have been skeptical of their findings and likewise have been unable to copy this knowledge, however hardly ever had a voice within the debate:

“The spotty proof that Aβ*56 performs a task in Alzheimer’s had [long] raised eyebrows.⁶ Wilcock has lengthy doubted research that declare to make use of ‘purified’ Aβ*56. Such oligomers are notoriously unstable, changing to different oligomer varieties spontaneously. A number of varieties might be current in a pattern even after purification efforts, making it laborious to say any cognitive results are on account of Aβ*56 alone, she notes — assuming it exists.

In reality, Wilcock and others say, a number of labs have tried and failed to seek out Aβ*56, though few have printed these findings. Journals are sometimes tired of destructive outcomes, and researchers might be reluctant to contradict a well-known investigator.”

The Amyloid Scandal

On the finish of 2021, a neuroscientist doctor was employed by traders to judge an experimental Alzheimer’s drug and found indicators that its knowledge consisted of doctored Western Blots (and subsequently inaccurate assessments of what oligomers have been current inside analysis topics’ brains).⁷ As he explored the subject additional, he found different papers throughout the Alzheimer’s literature had been flagged for holding doctored Western Blots.

Notice: Western blots, used to check for proteins, are one of many few simply detectable types of analysis fraud (e.g., we found Pfizer submitted pretend Western blots to regulators to “show” their vaccine labored). Regrettably, way more undetectable fraud exists all through the scientific literature (e.g., unbiased researchers evaluating regulatory submissions found Pfizer additionally submitted doctored knowledge on the place the COVID vaccine is distributed within the physique⁸).

Earlier than lengthy, the neuroscientist observed three of these suspect papers had been printed by the identical writer and determined to analyze the writer’s different publications. This led him to the seminal 2006 Alzheimer’s publication, which contained clear indicators of fraud.⁹

As investigation then uncovered 20 doctored papers written by the writer, 10 of which pertained to Aβ*56 (together with a co-researcher testifying to earlier scientific misconduct by the writer).

The Amyloid Business

One of many exceptional issues about this monumental fraud was how little was performed about it. For instance, the NIH was notified in January 2022, but in Could 2022, past nothing being performed, the NIH gave the suspect researcher a coveted $764,792 analysis grant (signed off by one other one of many authors of the 2006 paper¹⁰).

In July 2022, Science printed an article exposing the incident and the clear fraud that had occurred.¹¹ Regardless of this, the researcher was allowed to stay in his place as a tenured medical faculty professor.¹² It was not till June 2024 that the 2006 article was retracted on the request of the authors¹³ — all of whom denied being at fault and insisted the doctored pictures had not affected the article’s conclusions.

Ultimately, on January 29, 2025, throughout his affirmation listening to, RFK cited the paper for example of the institutional fraud and wasted tax {dollars} throughout the NIH, and some days later, the suspect researcher introduced his resignation from the medical faculty professorship (whereas nonetheless sustaining his innocence).¹⁴

This odd habits (e.g., the medical subject continues to insist the confirmed fraud has not disproven the Amyloid speculation) seemingly outcomes from how a lot cash is at stake — past the analysis {dollars}, roughly 7 million adults have Alzheimer’s — equating to tons of of billions in potential (Medicare funded) gross sales annually.¹⁵

The Failed Amyloid Medicine

Just lately, a monoclonal antibody that made immune cells goal amyloid demonstrated restricted success in treating Alzheimer’s — which was embraced as revolutionary by the medical neighborhood, the pharmaceutical trade, and drug regulators. In flip, the primary new drug obtained accelerated approval (which the FDA proudly introduced).¹⁶ The second then obtained a quiet backdoor approval (because of the immense controversy surrounding the primary),¹⁷ and the third was partially accepted a yr and a half later.¹⁸

Annually, JP Morgan (Chase Financial institution) hosts a non-public convention for pharmaceutical traders that units the tone for your complete trade. In 2023, its focus (lined intimately right here) was on the unimaginable profitability of the brand new Alzheimer’s medication and the GLP-1s like Ozempic (which the FDA has additionally relentlessly promoted). Most remarkably, the (extensively considered as corrupt) FDA commissioner was a keynote speaker, and some days earlier than the convention, had enacted the second backdoor approval.

Nonetheless, regardless of the rosy photos painted across the medication (which every attacked completely different elements of amyloids), they have been extremely controversial as:

The second monoclonal antibody (which focused amyloid precursors) had a considerably higher threat profit profile²² (solely 21% skilled mind bleeding and swelling on account of decreased focusing on of secure amyloid plaques), and 26.4% discount within the development of Alzheimer’s was detected within the trial (which for context, translated to a 0.45 discount on a scale the place a discount of not less than 1 to 2 factors is required to create an affect which is in any manner significant for a affected person).

The third monoclonal (which focused amyloid plaques considered extra pathologic)²³ was additionally contested because it brought on 36.8% of recipients to develop mind bleeding or swelling, like the opposite amyloid medicines, steadily brought on complications and infusion reactions (e.g., nausea, vomiting, adjustments in blood strain, allergic reactions or anaphylaxis) and there have been causes to suspect the trial had enormously overstated its minimal advantages.

Remarkably, regardless of widespread protest in opposition to the third drug, the FDA’s new advisory panel voted unanimously in favor of it, though it had a really related mechanism, efficacy, and toxicity to the beforehand unanimously rejected amyloid drug.

It ought to subsequently come as no shock that, when the British Medical Journal carried out an unbiased investigation, it discovered that, inside publicly obtainable databases, 9 out of 9 (assessable) members of the advisory committee had important monetary conflicts of curiosity.²⁴

Happily, regardless of the aggressive promotion of amyloid medication and the trade’s greatest makes an attempt to advertise the sector, the market considerably acknowledged how unhealthy they have been. The primary drug had its worth halved (then was withdrawn as nobody needed it — making round 5 million {dollars} whole),²⁵ whereas the opposite two have had very modest gross sales (e.g., 290 million for the most well-liked one²⁶).

What Amyloids Medicine Present Us

From this, 4 issues stand out:

For instance, a randomized managed trial which gave MCTs derived from coconut discovered that over 6 months,²⁷ 80% remained secure or improved — which for context, is best than what any of the amyloid drug trials confirmed, and extra importantly, doesn’t trigger mind bleeds (and prices quite a bit lower than the annual tough $30,000 value for these medication).

Notice: Quite a few readers have shared that coconut oil improved their relative’s dementia.

Likewise, only a few are conscious of a 2022 examine that ought to have revolutionized your complete Alzheimer’s subject:²⁸

Notice: The RECODE protocol was primarily based round figuring out the underlying reason behind a affected person’s cognitive impairment (as 5 various things could cause dementia), after which offering applicable pure therapies to deal with the relevant trigger. Since then, many others have replicated its success of their sufferers.

DMSO and Dementia

Dimethyl Sulfoxide (DMSO) is a naturally occurring compound that has a wide range of distinctive therapeutic properties that permit it to rescue tissues from dying and revive these broken from earlier accidents — greatest demonstrated by many years of proof displaying DMSO can heal strokes, mind bleeds, extreme concussions, and spinal wire accidents and save sufferers from a lifetime of paralysis.

As lots of DMSO’s mechanisms straight counteract the processes that set off dementia, I’ve obtained many accounts like these from readers:

“My uncle’s spouse has dementia and has been unable to talk for over a yr. My mother lately visited them and instructed them about DMSO. He started to provide his spouse DMSO orally. After two weeks she started to speak once more.²⁹

I learn the article and started giving it to my 93 yr outdated mom in her juice each morning on the finish of November. She has had some type of dementia for over 15 years. Since taking the DMSO, she not suffers with extreme sundowners. She is extra ‘with it’ and may talk and chuckle with us. Her persona is again. She is crossing her legs once more and lifting her pinky finger when consuming her espresso. It’s quite a lot of little issues that make a distinction.

She is ready to perceive when I’m asking her to make use of the toilet. She is extra cognitive and has began coloring in her coloring books once more.³⁰

I deeply respect your posts on DMSO. You helped carry spontaneous interplay again into the lifetime of my father with Alzheimer’s.”³¹

Quite a few research help these experiences:

These outcomes have additionally been replicated in people:

Conclusion

The Alzheimer’s story illustrates how medical science’s relentless deal with commercializable merchandise has failed the nation. This have to be changed with prioritizing understanding the foundation causes of the power diseases we face.

Happily, now that MAHA can set nationwide well being coverage and unbiased media has damaged the media’s monopoly over the reality because of the lies we noticed all through COVID-19, increasingly more are stepping exterior the medical orthodoxy to pursue therapies that may truly heal them. A possibility like this has by no means existed earlier than, and it’s crucial every of us brings consideration to the necessity for actual drugs earlier than the window to basically change the observe of drugs closes.

Writer’s Notice: That is an abridged model of an extended article which discusses the precise causes and coverings for Alzheimer’s illness and the cognitive decline which precedes it. That article, together with extra hyperlinks and references, might be learn right here. Moreover, a companion article on how DMSO treats neurological accidents (e.g., strokes, mind hemorrhages, traumatic mind accidents, spinal paralysis and developmental delay) might be learn right here.

A Notice from Dr. Mercola In regards to the Writer

A Midwestern Physician (AMD) is a board-certified doctor from the Midwest and a longtime reader of Mercola.com. I respect AMD’s distinctive perception on a variety of matters and am grateful to share it. I additionally respect AMD’s need to stay nameless since AMD continues to be on the entrance traces treating sufferers. To seek out extra of AMD’s work, you should definitely try The Forgotten Aspect of Medication on Substack.

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