Semaglutide, generally recognized beneath the model names Ozempic and Wegovy, has taken the load loss world by storm. And, because it helps with weight reduction, it’s good for sort 2 diabetes, as weight reduction is the first solution to reverse the signs of sort 2 diabetes. Semaglutide does scale back urge for food since you really feel fuller longer. Nonetheless, it’s not a miracle treatment, and it comes with unwanted effects. I’ve written beforehand about Ozempic face, weight reduction plateaus, regaining weight after you cease Ozempic, ineffectiveness for some individuals, in addition to pure options and fiber-rich meals that naturally work like semaglutide, simply to a lesser diploma. However now a brand new facet impact is rising—SIBO (small intestinal bacterial overgrowth). So, let’s take a better have a look at this.
Understanding SIBO and Its Connection to Semaglutide
SIBO happens when extreme micro organism develop within the small gut, resulting in signs like bloating, diarrhea, stomach ache, and meals intolerances. An absence of intestine motility could also be a part of the reason for SIBO, together with a low manufacturing of hydrochloric acid within the abdomen. Ultimately, the pure defenses of the small gut are compromised, and SIBO outcomes.
The Printed Case Report of SIBO and Semaglutide
A case report revealed in Canadian Journal of Physiology and Pharmacology describes a 35-year-old male who managed to lose 50 kilos ( 22.7 kg) over 120 days on oral semaglutide. Although he had earlier lactose intolerance, it obtained worse whereas taking semaglutide. And he additionally developed a brand new gluten intolerance. Then about six months after discontinuing semaglutide, he was recognized with SIBO, suggesting the drug might have contributed to or made this situation worse. The truth that the meals intolerances didn’t simply go away when he stopped taking semaglutide is very regarding. Apparently, there was a change each within the GI tract motility and the micro organism that loved these circumstances that endured after the drug was stopped.
How Semaglutide May Contribute to SIBO
Semaglutide’s principal impact is slowing down the emptying of the abdomen and slowing down intestinal transit. That impact makes you are feeling full longer for sue, however it additionally creates the right setting for micro organism to proliferate within the small gut. Micro organism die-off within the abdomen isn’t good, and the micro organism load may be substantial. So, even when 1 in 10,000 micro organism get by, however they get to hang around within the small gut and adapt resistance to bile salts, then they’ll colonize the small gut and reside off the sugars and quick chain carbohydrates that come their means.
This case report is simply from one man, however anecdotal experiences from different clinicians counsel that is removed from the one case. If you have already got sort 2 diabetes, and have any sort of meals intolerances, this new facet impact ought to provide you with pause. Do you actually need to take care of SIBO?
Semaglutide’s Facet Impact Checklist is Getting Longer
In our earlier articles about weight reduction and semaglutide, we’ve lined a number of unwanted effects related to semaglutide. “Ozempic Face: How you can Lose Weight With out Trying Older” mentioned the gaunt, aged look some customers expertise as a result of fast fats and muscle loss when taking semaglutide. “How you can Overcome a Weight Loss Plateau” explored why progress stalls for some. Within the article “Battling Ozempic Not Working? Right here’s How you can Repair It” I talked about how Ozempic doesn’t work for everyone, and the widespread myths that individuals imagine about weight reduction medication. I didn’t discuss concerning the uncommon unwanted effects like elevated threat of pancreatitis.
SIBO provides a complete new sort of facet impact to the checklist. In contrast to beauty considerations about Ozempic face, or plateauing weight reduction, SIBO actually impacts your high quality of life. It’s in all probability worse than the diabetes itself. You need to no less than quickly use a low FODMAP weight loss program to handle the bloating and diarrhea. It’s a very restrictive weight loss program and doesn’t actually allow you to get higher both.
For some individuals, the trade-off of simple weight reduction with Ozempic for a power case of SIBO. I do know a number of individuals who have struggled with SIBO for years and nonetheless haven’t overcome it. I feel coping with sort 2 diabetes is far simpler than overcoming SIBO. Making an attempt to vary entrenched micro organism within the intestinal tract is a tough proposition.
We’ve a number of articles about concepts for sustainable weight reduction. You possibly can see an summary of them within the article, “The Full Information to Wholesome Weight Loss: What Works and Why.” In any case, even with weigh loss medication, to achieve success long-term you need to study to eat wholesome meals, and get train to take care of weight reduction.
Conclusion: Is Semaglutide Well worth the Dangers?
Semaglutide is a strong drug for serving to individuals drop some weight. Nevertheless it has drawbacks. If you find yourself with SIBO, you may need wished that you just had by no means taken the drug to start out with. It isn’t recognized but how prevalent the incidence of SIBO is with semaglutide use. But when you have already got meals intolerances, you in all probability have a better probability of SIBO with the drug.
As talked about above, you need to take a look at our information on sustainable weight reduction suggestions. There are options to happening a crash course with Ozempic.
